VYAPAM was initially set-up as Pre Medical Test Board by Government of Madhya Pradesh in the year 1970. Later, in the year 1981, Pre Engineering Board was constituted. Soon after, in the year 1982 both these Boards were amalgamated and named as Madhya Pradesh Professional Examination Board (M.P.P.E.B.). Madhya Pradesh Professional Examination Board by Govt. Order No.1325-1717-42-82 dated 17.04.1982 has been assigned the responsibility of conducting entrance tests for admission to various colleges in the state. M.P.P.E.B. presently organizes many entrance tests.